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July 16, 2025

VO2 Max, FatMax & Threshold Testing: What the Science Really Says

At Different Health, we use clinical-grade aerobic testing to give high-performers a clear edge. VO2 Max, FatMax, and threshold metrics don’t just apply to athletes, they’re predictors of your energy, resilience, and even lifespan¹.

VO2 Max = Your Longevity Meter

VO2 Max measures how much oxygen your body can use during physical effort. The higher your VO2 Max, the better you perform under stress, physically and cognitively. High VO2 Max means lower mortality risk², better brain health and cognitive sharpness³, more energy, faster recovery, and fewer sick days. 

Dr. Peter Attia, a leading voice in longevity medicine, calls VO2 Max “perhaps the best objective metric for longevity.” In his deep dive on VO2 Max and lifespan, he breaks down how improving this one number can dramatically shift your long-term health trajectory—even reducing all-cause mortality by 4–5x in the highest performers.

Most wearables estimate it, and are 25%+ inaccurate. We measure it directly, using lab-grade, breath-by-breath analysis for precision accuracy.

Thresholds = More Efficient Training

Ever heard of “Zone 2”?

Your aerobic and anaerobic thresholds reveal when your body shifts fuel sources, from fat to carbs, as intensity rises. Knowing this helps you train smarter, burn fat more efficiently, and delay fatigue. That means more productive sessions, more fat burn, and more results. These thresholds are key to understanding how long you can sustain effort, and how efficiently your body recovers afterward.

When you train at the right threshold, you build endurance, improve fat metabolism, and reduce burnout⁴. It’s the foundation of zone-based training that actually works.

The problem? Most people guess their zones and get them wrong. That leads to missed gains, slower progress, and unnecessary fatigue.

At Different Health, we use precision threshold testing to pinpoint your exact training zones, so every session has a purpose and every effort counts.

FatMax = Smarter Weight Management

FatMax testing identifies the exact intensity at which your body burns the highest percentage of fat for fuel, a key metric for optimizing weight loss, endurance, and metabolic flexibility.

Training at your FatMax zone helps you build a faster metabolism, improve insulin sensitivity, and maintain stable energy levels throughout the day. It also supports better performance during both training and fasting by enhancing mitochondrial efficiency.

We use FatMax testing to create personalized protocols that improve fat-burning capacity, support weight management, and strengthen your metabolism, even while you’re at rest.

Whether you are training, leading, or building a sharper, longer-lasting mind and body, this is the foundation. You can’t guess your way to peak performance.

Ready to test your VO2 Max, Thresholds, and FatMax? Book a baseline assessment at Different Health and get a clear path forward.

Disclaimer: This content is for informational purposes only and is not intended as a substitute for medical advice, diagnosis, or treatment.

Sources

  1. Ross, R., Blair, S. N., Arena, R., et al. (2016). Importance of assessing cardiorespiratory fitness in clinical practice. Journal of the American College of Cardiology, 67(5), 575–588.
  2. Kodama, S., Saito, K., Tanaka, S., et al. (2009). Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA, 301(19), 2024–2035.
  3. Smith, P. J., Blumenthal, J. A., Hoffman, B. M., et al. (2010). Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosomatic Medicine, 72(3), 239–252.
  4. Seiler, S., & Kjerland, G. Ø. (2006). Quantifying training intensity distribution in elite endurance athletes: is there evidence for an “optimal” distribution? Scandinavian Journal of Medicine & Science in Sports, 16(1), 49–56.

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